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Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)

Hydroxyzine, mizolastine, and first-generation antihistamines such as chlorphenamine and promethazine should be used with caution or avoided where possible

A comprehensive review published in the journal Nutrients outlines its central role in skin health, describing how vitamin C supports collagen synthesis and helps neutralize free radicals generated by everyday environmental stress, including UV exposure

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